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Two type IV secretion systems with different functions in Burkholderia cenocepacia K56-2

¹ Univ. California -Davis;
² University of Michigan;
³ Texas A&M University

Bacterial type IV secretion systems (T4SS) perform two fundamental functions related to pathogenesis: the delivery of effector molecules to eukaryotic target cells and genetic exchange. Two T4SSs have been identified in Burkholderia cenocepacia K56-2, a representative of the ET12 lineage of the Burkholderia cepacia complex (Bcc). The Ptw T4SS encoded on a resident 92-kb plasmid is a chimera composed of VirB/D4 and F-specific subunits and is responsible for the translocation of effector(s) that have been linked to the plant tissue watersoaking (Ptw) phenotype. The bc-VirB/D4 system located on the chromosome II displays homology to the VirB/D4 T4SS of Agrobacterium tumefaciens. In contrast to the Ptw T4SS, the bc-VirB/D4 T4SS was found to be dispensable for plant watersoaking effector(s) secretion, but was found to be involved in plasmid mobilization. The fertility inhibitor Osa did not affect the secretion of watersoaking effector(s) via the Ptw system but did disrupt the mobilization of a RSF1010 derivative plasmid.

⁴ E-mail: cf-gonzalez{at}tamu.edu